dc.contributor.advisor | Cubillos Abello, Karen Andrea | |
dc.contributor.author | Prieto Cerquera, Bleidy Yelissa | |
dc.contributor.author | Salazar Quintero, Angie Daniela | |
dc.date.accessioned | 2022-10-03T19:38:14Z | |
dc.date.available | 2022-10-03T19:38:14Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://repositorio.unicolmayor.edu.co/handle/unicolmayor/5675 | |
dc.description.abstract | La microbiota intestinal es la comunidad de microorganismos vivos residentes en el tubo
digestivo, compuesta por bacterias, virus y hongos, que se adquieren después del nacimiento y
que cumplen varias funciones importantes.La microbiota intestinal está determinada por
factores como la edad, la alimentación, la genética, el ambiente, entre otros. Se ha descubierto
que existe una relación entre la disbiosis o alteración de la composición de la microbiota y el
desarrollo de enfermedades autoinmunes, inflamatorias y enfermedades neurodegenerativas
como la enfermedad de Parkinson (EP) y el Alzheimer (EA).
Estudios evidencian que el intestino y el sistema nervioso central (SNC) se comunican entre
sí. La secuenciación del gen de ARN ribosómico 16S (ARNr) pone en evidencia que la
microbiota intestinal bacteriana se encuentra alterada en algunas enfermedades
neurodegenerativas y comprueba que la diversidad de la microbiota intestinal disminuye sobre
todo en edades adultas. Esto, explica que el envejecimiento puede aumentar la inflamación
intestinal y cambiar los taxones bacterianos; así se incrementan las bacterias proinflamatorias
y disminuyen las bacterias antiinflamatorias, desencadenando inflamación sistémica del SNC,
lo que resulta en una neurodegeneración.
En esta monografía se ofrece una revisión bibliográfica, donde se busca comparar la microbiota
intestinal en personas sanas y en personas con enfermedades neurodegenerativas y relacionar
la disbiosis intestinal con el desarrollo de estas enfermedades. Así mismo, se pretende
contribuir en futuras investigaciones sobre el uso de estrategias que permitan mejorar el
proceso de diagnóstico y pronostico temprano en el desarrollo de enfermedades crónicas del
sistema nervioso y asi llegar a evitar la manifestacion de sintomasneurologicos que bajan la
calidad de vida humana. | spa |
dc.description.tableofcontents | TABLA DE CONTENIDO
Resumen
Introducción
Objetivos
1. Marco Teórico
1.1 Antecedentes
1.2 Enfermedades Neurodegenerativas
1.2.1 Enfermedad de Alzheimer
1.2.1.1 Características Clínicas
1.2.1.2 Diagnóstico
1.2.2 Enfermedad de Parkinson
1.2.2.1 Características Clínicas
1.2.2.2 Diagnóstico
1.3 Microbiota Intestinal
1.3.1 Funciones de la Microbiota
1.3.2 Métodos para el estudio de la microbiota intestinal
2. Diseño metodológico
2.1 Tipo de investigación
2.2 Alcance de la investigación
2.3 Población objeto de muestra
2.4 Muestra del análisis
3. Resultados
3.1 Fuentes de investigación
3.2 Resultados de la revisión bibliográfica
3.2.1 Ecología intestinal de la Enfermedad de Alzheimer
3.2.2 Ecología intestinal de la Enfermedad de Parkinson
3.2.3 Eje Microbiota-Intestino-Cerebro
3.2.4 Eje Microbiota-Intestino-Cerebro en enfermedad y la inmunidad
3.2.5 Eje Microbiota-Intestino-Cerebro en enfermedad de Alzheimer
3.2.6 Eje Microbiota-Intestino-Cerebro en enfermedad de Parkinson
4. Discusión
5. Conclusione | eng |
dc.format.extent | 48p. | spa |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | spa | spa |
dc.rights | Derechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2022 | spa |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | spa |
dc.title | Microbiota intestinal en pacientes con enfermedades neurodegenerativas: Revisión bibliográfica | spa |
dc.type | Trabajo de grado - Pregrado | spa |
dc.description.degreelevel | Pregrado | spa |
dc.description.degreename | Abogado(a) | spa |
dc.publisher.faculty | Facultad de Ciencias de la Salud | spa |
dc.publisher.place | Bogota | spa |
dc.publisher.program | Bacteriología y Laboratorio Clínico | spa |
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dc.rights.accessrights | info:eu-repo/semantics/closedAccess | spa |
dc.rights.creativecommons | Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0) | spa |
dc.subject.lemb | Parkinson | |
dc.subject.lemb | Alzheimer | |
dc.subject.proposal | Microbiota intestinal | spa |
dc.subject.proposal | Enfermedades neurodegenerativas | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_7a1f | spa |
dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
dc.type.content | Text | spa |
dc.type.driver | info:eu-repo/semantics/bachelorThesis | spa |
dc.type.redcol | https://purl.org/redcol/resource_type/TP | spa |
dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
dc.rights.coar | http://purl.org/coar/access_right/c_14cb | spa |