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Revisión documental de la relación de porphyromonas GINGIVALIS y los Anticuerpos anti-péptido citrulinado cíclico en la artritis Reumatoidea

dc.contributor.advisorCastro Molina, Susan Lorena
dc.contributor.authorPinilla Torres, Laura Lizeth
dc.date.accessioned2022-10-03T16:36:46Z
dc.date.available2022-10-03T16:36:46Z
dc.date.issued2022
dc.identifier.urihttps://repositorio.unicolmayor.edu.co/handle/unicolmayor/5674
dc.description.abstractPorphyromonas gingivalis es un anaerobio facultativo, Gram negativo con forma cocobacilar, no posee flagelos por lo que es inmóvil, es uno de los microorganismos que con mayor frecuencia se encuentra implicado en la formación de biofilm dental subgingival, por lo que se asocia principalmente con patologías orales como la periodontitis, esta se caracteriza por producir inflamación gingival, produciendo en los casos más graves, degradación de las encías y pérdida ósea. Uno de los factores de virulencia que se encuentran implicados en el desarrollo crónico de la periodontitis es la presencia de la enzima peptidil arginina deaminasa (PPDA), la cual se considera como homóloga a la peptidil arginina deaminasa humana (PAD), implicada en el desarrollo de anticuerpos anti péptido citrulinado cíclico ( Anti - CCP), estos se desarrollan gracias a la catálisis de la arginina en citrulina por medio de esta enzima lo que conlleva a un cambio postransduccional dando como resultado dicha modificación, esto se produce gracias a la activación de la enzima al haber altos niveles de calcio intracelular cuando hay apoptosis o daño celular como en el caso de la artritis reumatoide (AR) por lo que estos anticuerpos se han usado como diagnóstico y pronóstico de esta enfermedad. En la presente revisión se explicarán las posibles formas en las que la enzima PPDA y P. gingivalis son capaces de producir Anti CCP y relacionarse con la AR.spa
dc.description.tableofcontentsTABLA DE CONTENIDO RESUMEN.7 INTRODUCCIÓN..8 1. Planteamiento del problema...9 2. Objetivos ....10 2.1 Objetivo General 10 2.3 Objetivos Específicos10 3. Justificación ......11 4. Antecedentes.....11 5. Marco Teórico ..22 5.1 Porhyromonas gingivalis:...22 5.1.1 Factores de Virulencia .23 5.2 Enfermedad periodontal: ...24 5.3 Anticuerpos Anti-Proteínas Citrulinadas (ANTI-CCP). 25 5.4 Artritis Reumatoide .27 5.4.1 Factores de Riesgo.29 6. Diseño metodológico...31 6.1 Tipo de investigación: .....31 6.2 Alcance de la investigación.31 6.3 Población..32 6.4 Muestra ....32 6.5 Variables ..32 6.5.1 Variable dependiente ...32 6.5.2 Variable independiente 32 7. Metodología ......33 7.1 Revisión bibliográfica .....33 7.2 Selección de material bibliográfico.33 8. Resultados..34 9. Discusión ....41 10. Conclusiones ...45 11. Referencias.....46spa
dc.format.extent57p.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.rightsDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2022eng
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.titleRevisión documental de la relación de porphyromonas GINGIVALIS y los Anticuerpos anti-péptido citrulinado cíclico en la artritis Reumatoideaspa
dc.typeTrabajo de grado - Pregradospa
dc.description.degreelevelPregradospa
dc.description.degreenameBacteriólogo(a) y Laboratorista Clínicospa
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.placeBogotáspa
dc.publisher.programBacteriología y Laboratorio Clínicospa
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dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.lembInflamación
dc.subject.lembBacteria
dc.subject.lembEnzima
dc.subject.proposalAnticuerposspa
dc.subject.proposalPeriodontitisspa
dc.subject.proposalAutoinmunidadspa
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dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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dc.type.redcolhttps://purl.org/redcol/resource_type/TPspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.rights.coarhttp://purl.org/coar/access_right/c_14cbspa


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